Subsidiary capability upgrading and parent-subsidiary relationship: insights from a Chinese acquisition in the UK

Purpose: - This study aims to explore capability upgrading of EMNE’s subsidiaries in developed countries and how the parent-subsidiary relationship influences such upgrading. Design/methodology/approach: - The study adopts an interdisciplinary approach to capability upgrading of EMNEs subsidiaries in developed countries. It employs a single case study to explore this under-research area. Finding: - the analysis challenges the orthodox view and suggests broad based capability upgrading has taken place in the EMNE acquired subsidiaries ranging from product, process, functional to intersectoral. In addition, the capability upgrading was contingent on the degree of subsidiary autonomy and subsidiary mandates. Originality/value: - This study represents one of the first to examine capability upgrading and parent-subsidiary relationship in the context of EMNEs’ internationalisation activities

Egypt’s Pediatric Oncology Hospital 57357: A Case Study Analysis

Hospital 57357 is the foremost pediatric oncology hospital in Egypt and provides treatment free of charge to children with cancer. Since its establishment in 2007, the hospital has grown to a capacity of 380 patient beds across three locations. Its quest for continuous improvement led to the development of a new performance management system emphasizing the tracking and measurement of a multitude of Key Performance Indicators across all departments. While this new system enables objective and perpetual monitoring of key patient care metrics, its integration into the existing structure introduces challenges that must be addressed. To analyze the external environment of Egypt’s healthcare industry and the hospital’s position in the market, a PESTEL analysis, Porter’s Five Forces analysis, and VRIO analysis were conducted. These analyses inform recommendations for addressing the current challenges faced by the organization. Proposed recommendations include improving physician documentation efficiency, increasing transparency and communication, and creating a recognition system for subjective achievements. Keywords: pediatric oncology, healthcare industry, Egypt, performance management syste

An integrated approach to the interpretation of Single Amino Acid Polymorphisms within the framework of CATH and Gene3D

Background: The phenotypic effects of sequence variations in protein-coding regions come about primarily via their effects on the resulting structures, for example by disrupting active sites or affecting structural stability. In order better to understand the mechanisms behind known mutant phenotypes, and predict the effects of novel variations, biologists need tools to gauge the impacts of DNA mutations in terms of their structural manifestation. Although many mutations occur within domains whose structure has been solved, many more occur within genes whose protein products have not been structurally characterized.Results: Here we present 3DSim (3D Structural Implication of Mutations), a database and web application facilitating the localization and visualization of single amino acid polymorphisms (SAAPs) mapped to protein structures even where the structure of the protein of interest is unknown. The server displays information on 6514 point mutations, 4865 of them known to be associated with disease. These polymorphisms are drawn from SAAPdb, which aggregates data from various sources including dbSNP and several pathogenic mutation databases. While the SAAPdb interface displays mutations on known structures, 3DSim projects mutations onto known sequence domains in Gene3D. This resource contains sequences annotated with domains predicted to belong to structural families in the CATH database. Mappings between domain sequences in Gene3D and known structures in CATH are obtained using a MUSCLE alignment. 1210 three-dimensional structures corresponding to CATH structural domains are currently included in 3DSim; these domains are distributed across 396 CATH superfamilies, and provide a comprehensive overview of the distribution of mutations in structural space.Conclusion: The server is publicly available at http://3DSim.bioinfo.cnio.es/. In addition, the database containing the mapping between SAAPdb, Gene3D and CATH is available on request and most of the functionality is available through programmatic web service access

The relationship between physical activity, appetite and energy intake in older adults: a systematic review

Ageing often causes a reduction in appetite and energy intake in older adults which can result in malnutrition. Current guidelines for older adults suggest increasing physical activity to enhance appetite. However, it is unclear if there is evidence to support this advice. This aim of this review is to assess if appetite and energy intake is changed in older adults that undertake acute or regular physical activity (measured from cross sectional and intervention studies). Databases SPORTDiscus, CINAHL, MEDLINE were searched for studies between 1970 and 2017 using search terms related to ageing, physical activity (including exercise), energy and appetite. Studies included contained adults over 60 years, including acute, cross-sectional and intervention (longitudinal) studies. Of 34 full-text articles assessed, 8 were included. The Cochrane Collaboration's tool was used for assessing risk of bias. No acute studies were found. Of the cross-sectional studies, one study suggested that individuals who undertake habitual physical activity had an increased energy intake and none of the studies found differences in appetite ratings. Energy intakes increased in the intervention studies, though not always sufficiently to maintain energy balance. One study showed that ability to correctly compensate for previous energy intake was better in those that undertake habitual physical activity. The limited number of studies, wide range of data collection methodologies, time-scales and interventions mean that definitive outcomes are difficult to identify. At this stage advice to increase acute or habitual physical activity as a mean to increase appetite is not supported by sufficient evidence

Colloidal templating at a cholesteric - oil interface: Assembly guided by an array of disclination lines

We simulate colloids (radius $R \sim 1\mu$m) trapped at the interface between a cholesteric liquid crystal and an immiscible oil, at which the helical order (pitch p) in the bulk conflicts with the orientation induced at the interface, stabilizing an ordered array of disclinations. For weak anchoring strength W of the director field at the colloidal surface, this creates a template, favoring particle positions eitheron top of or midway between defect lines, depending on $\alpha = R/p$. For small $\alpha$, optical microscopy experiments confirm this picture, but for larger $\alpha$ no templating is seen. This may stem from the emergence at moderate W of a rugged energy landscape associated with defect reconnections.Comment: 5 pages, 4 figure

ELECTROMECHANICAL DELAY AND REACTIVE STRENGTH INDICES OF SPRINT AND ENDURANCE TRAINED ATHLETES

This study compared reactive strength indices and electromechanical delay in muscle of competitive sprint and endurance athletes. Reactive strength indices were obtained from five sprinters and six endurance athletes who completed drop jumps on a force-sledge apparatus at various drop heights. Electromechanical delay times were also obtained 011 the ankle plantar flexors while performing a simple heel raise activity. The results indicated that sprinters had significantly higher RSI scores at all drop heights. Sprint athletes also had significantly shorter electromechanical delay times indicating a capacity for generating force more rapidly and the likelihood of stiffer musculotendinous structures

Power, discursive practices and the construction of the "real"

Starting with a critique of the epistemological and ontological bases of neo-institutionalism, in this article we defend the potential for the application of post-structuralist perspectives to the institutional approach. We contend that this theoretical approach, which incorporates an element, traditionally overlooked in institutional analyses, namely power, has the advantage of contributing to an enhanced comprehension of the dynamics of institutionalization. In conclusion, we believe that the area of organizational studies would benefit by a more all-encompassing vision of the processes of institutionalization, which would include power at its core, instead of considering institutions as non-changing variables. Undoubtedly, if we take empirical research into consideration, what we need is, from a historical perspective, understand the way by which the main discourses or narratives constitute, transform and are transformed by our objects of investigation, among which organizations certainly occupy a central place